The effect Of MSC-conditioned medium (MSC-CM) low dosage on urea levels in acute renal failure rats

Background: Acute renal failure (ARF) is associated with a high incidence of morbidity and mortality, as well as a high risk of developing chronic renal failure that is associated with elevation of urea level. The kidneys have an extraordinary ability to regenerate after injury and fully recover, and clinical options are limited to fluid management and dialysis procedures. The development of new strategies to increase the ability of kidney regeneration due to ARF, and to maintain kidney function both in the short term and in the long term is needed.Objective: This study aims to determine the effect of low-dose MSC-CM on urea levels in ARF.Method: In this study, 12 male gentamicin-induced Wistar rats were divided into 2 groups control (intravenous PBS administration) and treatment (intravenous MSC-CM low-dose at 0,2 cc). Parameters including urea-urine level were measured spectrophotometer and then analyzed by unpaired T-test.Result: The results of this study showed that the mean urea levels between the control group (19.46 ± 0.56 mg / dL) and the treatment group (13.96 ± 0.73 mg / dL) were significantly different (p <0.05).Conclusion: The conclusion of this study indicated that there was an effect of lowdose ofMSC-CMon urea levels in acute renal failure.