Impact of oxidative stress in COPD exacerbations: clinical evidence on N-Acetylcysteine

Chronic Obstructive Pulmonary Disease (COPD), defined by The American Thoracic Society (ATS) is a disease marked by limitation of airflow due to emphysema or chronic bronchitis, the obstruction is usually progressive, and can be accompanied by hyper-reactivity of the airway, and may be reversible. The European Respiratory Society defined COPD as decline in the maximal expiration flow and slow lung clearance, is progressive, and mostly irreversible. According to The Global Initiative for Chronic Obstructive Lung Disease (GOLD), COPD is a disease where there is limitation of airflow that is progressive, associated with abnormal inflammatory responses from the lungs towards hazardous gases or particles