Pachyphyllanone, a new cycloartane triterpenoid isolated from Aglaia pachyphylla and its cytotoxic activity

Dimensions

Safriansyah, Wahyu and Juliansyah, Endang and Rustaman, Rustaman and Naini, Al Arofatus and Farabi, Kindi and Azmi, Mohamad Nurul and Nafiah, Mohamad Azlan and Kuncoro, Hadi and Supratman, Unang and Fajriah, Sofa and Harneti, Desi (2025) Pachyphyllanone, a new cycloartane triterpenoid isolated from Aglaia pachyphylla and its cytotoxic activity. Journal of Asian Natural Products Research, 27 (7). pp. 1072-1079. ISSN 1028-6020

Full text not available from this repository. (Request a copy)

Official URL: https://doi.org/10.1080/10286020.2024.2446280

Abstract

Aglaia pachyphylla is a species from the Aglaia genus (Meliaceae) and the chemical constituent has not been widely explored. A new cycloartane-type triterpenoid, pachyphyllanone (1), along with four known compounds (2-5) were isolated from Aglaia pachyphylla Miq. Furthermore, the structure of the new compound was elucidated by the interpretation of spectroscopic data, including 1D and 2D-NMR, as well as ECD and NMR calculations (DP4+ analysis). Compounds 1-5 showed cytotoxic activities against MCF-7 with IC50 values ranging from 160.74 to 299.75 μM.

Item Type:	Article
Uncontrolled Keywords:	Meliaceae; Aglaia pachyphylla; pachyphyllanone; MCF-7; cytotoxic activity
Subjects:	Medicine & Biology Chemistry
Depositing User:	Wagiyah
Date Deposited:	26 Dec 2025 18:27
Last Modified:	26 Dec 2025 18:27
URI:	https://karya.brin.go.id/id/eprint/57148

Actions (login required)

: View Item