Tirucallane-type triterpenoid from the stem bark of Chisocheton lasiocarpus and its cytotoxic activity against MCF-7 breast cancer cells

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Nurlelasari, Nurlelasari and Parulian, Samuel San and Naini, Al Arofatus and Hilmayanti, Erina and Farabi, Kindi and Harneti, Desi and Darwati, Darwati and Mayanti, Tri and Maharani, Rani and Herlina, Tati and Supratman, Unang and Anwar, Risyandi and Fajriah, Sofa and Azmi, Mohamad Nurul and Prescott, Thomas and Shiono, Yoshihito (2023) Tirucallane-type triterpenoid from the stem bark of Chisocheton lasiocarpus and its cytotoxic activity against MCF-7 breast cancer cells. Journal of Asian Natural Products Research, 25 (8). pp. 803-809. ISSN 1028-6020

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Abstract

Chisocarpene A (1) is a new tirucallane-type triterpenoid together with odoratone (2) and 24-methylenecycloartanol (3), isolated from the stem bark of Chisocheton lasiocarpus. The chemical structures of compounds 1–3 were elucidated through a detailed analysis of their spectroscopic data (IR, MS, 1 D, and 2 D NMR). The isolated compounds were evaluated for cytotoxic activity against the MCF-7 breast cancer cell line using a resazurin-based assay. Compound 1 showed the most potent activity (IC50 26.56 ± 1.01 µM) and was two-fold more active than the positive control.

Item Type: Article
Uncontrolled Keywords: Chisocheton lasiocarpus, Meliaceae, triterpenoid, cytotoxic activity, MCF-7
Subjects: Medicine & Biology
Chemistry
Depositing User: Rizzal Rosiyan
Date Deposited: 18 Dec 2025 02:51
Last Modified: 18 Dec 2025 02:51
URI: https://karya.brin.go.id/id/eprint/56609

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