The Anti-Filarial Antibodies Prevalence after Mass Drug Administration in Two Endemic Areas of Indonesia

Introduction: Lymphatic filariasis is a public health problem in Indonesia, and efforts to eliminate it began in 2006 in Belitung and in 2007 in Pekalongan City. It is endemic to LF, and MDA treatment has been implemented. The study’s goal is to find antifilarial IgG4 antibodies in the community after a lot of drug treatment for filariasis in places where Brugia malayi is common, like Belitung district, Kepulauan Bangka Belitung, and Pekalongan city, Central Java, where Wuchereria bancrofti is common. Method: We will conduct this study using serum-stored biological material and immunological techniques such as enzyme-linked immunosorbent assays (ELISA). Using ELISA, we examined a total of 196 serum samples in Belitung and 140 serum samples in Pekalongan. Results: The study results showed that the antibody prevalence in Belitung was 33.1% (665 out of 196) and 1.43% (2 out of 140). This study discovered a high prevalence of filariasis in children in Brugia-endemic communities. However, the study found lower rates of Bancroftian infection compared to adult communities. Conclusion: In Lassar, children still have a high prevalence of antibodies. In Gemar, the prevalence of antibodies tends to be low across all age groups. The Bm14 antibody test is a promising method for sero epidemiology. We recommend further research to identify suitable populations for transmission assessments.