Alpha-hydroxyisobutyric acid-assisted solid-liquid chromatography for the separation of lutetium-177 from neutron-irradiated natural ytterbium

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Billah, Aulia Arivin and Prasetya, Kukuh Eka and Triyatna, Fany and Sarwono, Daya Agung and Abidin, Abidin and Rindiyantono, Fernanto and Maiyesni, Maiyesni and Munir, Miftakul and Saptiama, Indra and Ritawidya, Rien and Zulys, Agustino (2024) Alpha-hydroxyisobutyric acid-assisted solid-liquid chromatography for the separation of lutetium-177 from neutron-irradiated natural ytterbium. Radiochimica Acta, 112 (3). pp. 175-181. ISSN 0033-8230

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Official URL: https://doi.org/10.1515/ract-2023-0234

Abstract

The production method of no-carrier added Lutetium-177 (177Lu) was developed from a neutron-activated natural ytterbium (Yb) using column chromatography separation method. Dowex W50 X8 resin and a combination of alpha-hydroxyisobutyric acid (α-HIBA) and hydrochloric acid (HCl) were used as column filler and eluent, respectively. HCl increased the desorption and separation between 177Lu and Yb at a concentration of 0.25 M, while the optimal α-HIBA concentration was 0.15 M, resulting in 177Lu yield of 81.19 % and low impurities (175Yb: 9.28 %, and 169Yb: 2.09 %). Nevertheless, further study using an enriched 176Yb target is essential to significantly increase the specific activity of 177Lu.

Item Type:	Article
Uncontrolled Keywords:	no-carrier added 177Lu; alpha hydroxyisobutyric acid; ion exchange chromatography; separation method
Subjects:	Chemistry > Photochemistry & Radiation Chemistry
Depositing User:	Maria Regina
Date Deposited:	13 Dec 2025 19:09
Last Modified:	13 Dec 2025 19:09
URI:	https://karya.brin.go.id/id/eprint/56239

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