Ameliorative effect of quercetin on pancreatic damage in rodent: a meta-analysis

Pancreatitis has the potential to occur with increasing cases of hyperlipidemiaand alcohol consumption. Meanwhile, until now pharmacotherapy for pan-creatitis is more emphasized for pain relief and lowering triglyceride levels (forHFD-induced pancreatitis). The polyphenol (quercetin) has several biologicalactivities, including anti-cancer, antiallergic, anti-inflammatory and ant-diabetic. This study aimed to evaluate the potential effect of quercetin totreat pancreatitis. After verification, 19 relevant articles were included in theanalysis, where Linear mix model analysis was applied to parameters includingblood glucose, pancreas islet number, insulin level, TBARS level, nuclear factorkappa B (NF-κB), endogenous antioxidant (GSH, SOD, CAT, GPx), TNFα, IL−6,Caspase 3 (Casp3) and IL−1b gene expression. The level quercetin was used asfixed effect and study setting as random effect. The administration of quercetinwas able to significantly increase the production of tissue insulin, restore theantioxidant defense system (increase SOD, GSH, decrease TBARS), and inhibitthe progression of inflammation based on the expression of NF-kB, TNFα and IL−6 genes. Therefore, the results of meta-analysis support the hypothesis thatquercetin is able to restore pancreatic function, and has the potential to bedeveloped to treat pancreatitis.ARTICLE HISTORYReceived 19 March 2023Revised 11 May 2023Accepted 4 June 2023KEYWORDSpancreatitis; oxidative stress;quercetin; linear-mixed-modelIntroductionHyperlipidemia is defined as an increase inplasma cholesterol, triglycerides, or both [1,2].Hypertriglyceridemia has been reported to bepositively correlated with cases of CVD and pan-creatitis [3]. Oxidative stress conditions on betacells and changes in plasma viscosity by trigly-cerides are mentioned as triggers for pancreaticcell damage, ranging from inflammation tonecrosis [4,5]. In the case of pancreatic cells,insulin secretion is impaired by the accumulationof free fatty acid (FFA), which can also lead toapoptosis [6]. Therefore, treatment of damagedpancreatic cells is needed, especially to reducethe dependence of diabetic patients on insulintherapy.A number of natural compounds that havelipid lowering activity include flavonoids, cou-marins, saponins, oligosaccharides, alkaloids,and organo sulfur [7,8]. One of the major mem-bers of flavonoids is quercetin (Figure 1).Quercetin is often used as an equivalenceCONTACT Tri Wiyono triwiyono.mm@gmail.com Research Center for Food Process and Technology (PRTPP), National Researchand Innovation Agency (BRIN), Yogyakarta, IndonesiaEGYPTIAN JOURNAL OF BASIC AND APPLIED SCIENCES2023, VOL. 10, NO. 1, 433–446https://doi.org/10.1080/2314808X.2023.2222467© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properlycited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with theirconsent.