Aaptamine, Isolated from the Bunaken National Park’s Sponge, Aaptos sp., Promotes Cell Cycle Arrest and Induces Necrotic Cell Death of Colorectal Cancers

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Fajarwati, Annisa Elcentia and Hardhiyuna, Mutia and Ningsih, Febby Nurdiya and Hermawan, Adam and Putri, Dyaningtyas Dewi Pamungkas and Fatimah, Nurul and Bayu, Asep and Setiawan, Andi and Arbi, Ucu Yanu and Murniasih, Tutik and Rosyidah, A’liyatur and Hadi, Tri Aryono and Putra, Masteria Yunovilsa and Ahmadi, Peni (2024) Aaptamine, Isolated from the Bunaken National Park’s Sponge, Aaptos sp., Promotes Cell Cycle Arrest and Induces Necrotic Cell Death of Colorectal Cancers. Acta Chimica Slovenica, 71 (4). pp. 619-626. ISSN 15803155

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Abstract

The sponge is one of the potential sources of bioactive compounds. Among them, the sponge Aaptos has been a promis-ing source of leading drugs including aaptamine (1). This study investigated the aaptamine (1), spectroscopically deter-mined, from Aaptos sp. collected from Bunaken National Park, Indonesia, as an anticancer agent, specifically targeting colorectal cancers (CRCs). Compound 1 showed potent cytotoxicity against DLD-1 and Caco-2 with IC50 values of 30.3 and 236.8 μg/mL, respectively. In addition, the exposure of compound 1 on those colorectal cancer cells could promote cell cycle arrest and induce necrotic cell death.

Item Type: Article
Uncontrolled Keywords: Sponge, Aaptos, aaptamine, DLD-1, Caco-2, Necroti
Subjects: Medicine & Biology
Depositing User: Maria Regina
Date Deposited: 09 Dec 2025 03:30
Last Modified: 09 Dec 2025 03:30
URI: https://karya.brin.go.id/id/eprint/55860

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