A bibliometric analysis of preclinical trials of Andrographis paniculata (Burm.f.) Nees in diabetes mellitus

The prevalence of diabetes mellitus has increased over time. Medicinal plants, including Andrographis panicu
lata (Burm.f) Nees, are recognized for their use to manage hyperglycemia. Nowadays, plenty of papers are
published about A. paniculata as an antidiabetic; however, no bibliometric study about the topic exists. This
study examines the existing papers about the preclinical trial of A. paniculata as an antidiabetic agent using
bibliometric analysis focusing on countries, institutions, publishers, authors, documents, and keywords. Bib
liographic information of relevant research and conference articles were obtained from the Scopus database.
In total, 97 articles published between 1994 and 2021 were selected, covering 376 authors and 1270 key
words. Data were analyzed bibliometrically using Vosviewer 1.6.16. A total of 97 published papers occurred
from 1994 to2021wereselected. India, Universitas Gadjah Mada (Indonesia), Journal of Ethnopharmacology,
and Agung Endro Nugroho (Universitas Gadjah Mada, Indonesia) were the most productive country, institu
tion, publisher, and author, respectively. The analysis of the most influential papers, co-citation network of
the most influential papers, bibliographical coupling network based on authors, and keyword co-occurrence
network and overlay demonstrated that the abundance and variety of existing papers about preclinical trials
of A. paniculata as an antidiabetic were from phytochemistry, pharmacology, and drug formulation. The find
ings of our analysis have implications for managerial and theoretical aspects on this topic, such as encourag
ing research collaborations by analyzing the contributions of countries, institutions, publishers, and authors
and revealing research gaps (molecular mechanisms, toxicities and side effects, drug formulations, and clini
cal trials) to accept a phytomedicine as a therapeutic option.