Comparison of neutralizing Sars Cov-2 Igg antibody levels in hospitalized patients At Dr. Mohammad Hoesin Palembang Hospital

Ahmad, Zen and Sudarto, Sudarto and Linda, RA and PP, Rouly and FR, Alif and Rasyidi, Syafran and Liana, Phey (2023) Comparison of neutralizing Sars Cov-2 Igg antibody levels in hospitalized patients At Dr. Mohammad Hoesin Palembang Hospital. Manuju : Malahayati Nursing Journal, 5 (5): 8. pp. 1380-1390. ISSN 2655-2728

[thumbnail of 2655-2728_5_5_2023-8.pdf]
Preview
Text
2655-2728_5_5_2023-8.pdf - Published Version

Download (290kB) | Preview

Abstract

COVID-19 is an acute respiratory disease that spreads rapidly throughout the world caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV- 2). Published research on levels of SARS-CoV-2 antibodies in hospitalized COVID-19 patients is still limited. Research on sero-epidemiology and its correlation with the clinical severity of COVID-19 is needed as a database for pandemic governance, especially research on neutralizing antibodies. This study was designed to compare the levels of IgG SARS CoV-2 on the tenth day in hospitalized patients with various clinical severity at RSUP Dr. Mohammad Hoesin Palembang. This research is an observational-analytic study with a cross-sectional design. The study was conducted in the COVID-19 isolation ward of RSMH Palembang from December 2021 to March 2022. IgG SARS CoV-2 level was measured in patients with confirmed COVID-19. Differences in IgG values of SARS CoV-2 were tested with the Mann Whitney test. The effect of various confounding variables in this study was tested using bivariate and multivariate tests in the form of a chi-square test and multiple linear regression on the scale of the dependent variable. The study included 50 patients, consisting of 22 patients with mild-moderate severity and 28 patients with severelycritically ill. Bivariate analysis showed there was no significant difference of IgG SARS-CoV-2 between two groups. From the data analysis using the ROC curve, the cut-off point for SARS-CoV-2 IgG levels in predicting the severity of COVID-19 disease was 500 AU/mL. IgG SARS-CoV-2 level of more than 500 AU/mL causes an increased risk of 3.69 (95% CI 1.13-11.98) times to suffer from severe-critical COVID-19. Serum IgG SARS-CoV-2 levels were found to be significantly higher in patients with severe-critical symptoms than patients with mild-moderate symptoms in COVID-19 hospitalized patients at Dr. Mohammad Hoesin Palembang hospital.

Item Type: Article
Uncontrolled Keywords: Severity of Covid-19, IgG SARS-CoV-2, Covid-19, Respiratory diseases
Subjects: Medicine & Biology
Medicine & Biology > Clinical Medicine
Depositing User: - Annisa -
Date Deposited: 02 Apr 2024 02:52
Last Modified: 02 Apr 2024 02:52
URI: https://karya.brin.go.id/id/eprint/23606

Actions (login required)

View Item
View Item