Carbon paste electrode modified by dibenzo-18-crown-6 for the determination of paracetamol using differential pulse voltammetry technique

Irdhawati, Irdhawati and Ni Ketut Shinta Mas, Methaninditya and Anak Agung Bawa, Putra (2023) Carbon paste electrode modified by dibenzo-18-crown-6 for the determination of paracetamol using differential pulse voltammetry technique. Indonesian Journal of Chemistry (Indones. J. Chem), 23 (1): 6. pp. 53-61. ISSN 1411-9420 e_ISSN: 2460-1578

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Abstract

The fabrication, optimization and validation of measurement using a modified carbon paste electrode (CPE) with dibenzo-18-crown-6 were carried out for the determination of paracetamol in commercial products. The pH, dibenzo-18-crown-6 concentration in carbon paste, and scan rate parameters were optimized. Validation of the measurement was observed from linear concentration range, LoD, LoQ, precision, and percentage of the recovery. The result showed that the optimum pH was at 2, the optimum concentration of dibenzo-18-crown-6 in carbon paste was 0.6%, optimum scan rates were 35 mV/s for CPE, and increased to 50 mV/s using modified CPE. The linear concentration range for CPE was obtained at 10-300 μM with LoD and LoQ of 28.88 and 96.28 μM, respectively. Meanwhile, CPE modified with dibenzo-18-crown-6 gave wider linear concentration range at 1–700 μM with LoD and LoQ of 52.36 and 174.53 μM, respectively. The CPE and modified CPE had good precision, with Horwitz ratio values of less than two. The percentage of recovery for two samples with three replicates measurements was obtained (89.81 ± 1.38)% and (108.02 ± 0.42)% for samples A and B, respectively. Dibenzo-18-crown-6 modified CPE was used for the determination of paracetamol in both samples yielding 97–98% compared with the paracetamol composition on its labels.

Item Type: Article
Additional Information: Validated by Sri Wulan
Uncontrolled Keywords: Carbon paste electrode, Dibenzo-18-crown-6, Differential pulse voltammetry, Paracetamol, Differential pulse anodic stripping voltammetry, Acetaminophen
Subjects: Chemistry > Analytical Chemistry
Chemistry > Physical & Theoretical Chemistry
Depositing User: - Een Rohaeni
Date Deposited: 08 Mar 2024 08:21
Last Modified: 08 Mar 2024 08:21
URI: https://karya.brin.go.id/id/eprint/22159

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