CALCULATION OF BNCT DOSIMETRY FOR BRAIN CANCER BASED ON KARTINI RESEARCH REACTOR USING THE PHITS CODE

CALCULATION OF BNCT DOSIMETRY FOR BRAIN CANCER BASED ON KARTINI
RESEARCH REACTOR USING PHITS CODE. Cancer is a dangerous disease caused by the growth
of a mass of cells that are unnatural and uncontrollable. Glioblastoma, also called as glioblastoma
multiforme (GBM), is one of dangerous brain cancer. The dismal prognosis associated with glioblastoma
is attributable not only to its aggressive and infiltrative behavior, but also to its location typically deep in
the parenchyma of the brain. In resolving this chalenge, the BNCT method can be a solution. This study
aims to calculate BNCT dosimetry in different of cancer positions and irradiation geometries using
PHITS code. The results show that the deeper the cancers target at brain the slower the total absorbed
dose rate of cancer target. It takes a longer treatment time. Based on the treatment time and total absorbed
dose rate of cancer target, the TOP irradiation geometry is an appropriate choice in treating the cancer
target in this case. To achieve the histopathological cure of GBM at the primary site, the absorbed dose of
brain was calculated to be 1.07 Gy and 1.64 Gy for the LLAT and PA irradiation geometry, respectively.
While, for cancer position of 3 cm, 5 cm, 7.15 cm, 9 cm, and 11 cm, the absorbed dose of brain is 0.25 Gy,
0.48 Gy, 0.85 Gy, 1.33 Gy, and 2.01 Gy, respectively. In addition to the stochastic effect, it was found
also deterministic effects that may be produced such as cataracts.