The effect of cyclodextrin addition towards preparation of atorvastatin nanoparticle for hypercholesterolemia drug

Atorvastatin is a material used in the pharmaceutical world as hypercholesterolemia drug. The addition of cyclodextrin as encapsulation media atorvastatin are expected to provide the amorphous nature of the material. This research will study the effect of adding cyclodextrin to dry milling process atorvastatin then characterized using Particle Size Analyzer (PSA), X-Ray Diffraction (XRD) and Scanning Electron Microscope (SEM). PSA test results showed that atorvastatin sample before milling was measured at 2386.7 ± 630.5 nm. After milling with addition of cyclodextrin resulted on size of 127.1 ± 503.2 nm. While the control without the addition of cyclodextrin after milling resulted in size of 446.6 ± 112.4 nm. XRD characterization results indicate that the formation of the amorphous phase is characterized by a widening of the peaks in the XRD data. SEM image further showed the amorphous characteristic of resulted atorvastatin nanoparticle. In conclusion, the addition of cyclodextrin was capable of producing amorphous properties towards nano-atorvastatin.