Fourier Transform Infra-Red spectrophotometry observation to find appropriate wavelength for non-invasive blood glucose level measurement optical device

The appropriate wavelength is essential for non-invasive blood glucose level measurement optical device. We conducted this experimental observation to find the usable wavelength candidate for non-invasive blood glucose level measurement optical device in 1000 nm to 2500 nm range. We run this observation in Prodia Bogor and Food Processing and Crops Technology Lab, Faculty of Agricultural Engineering, IPB University, July 2019. We obtained fasting, 15 mnt postprandial, and 30 mnt postprandial blood sample from 10 randomly selected consenting non blinded healthy adult subjects between 18 to 60 years old. We measuredspectrophotometric absorbance for each blood sample. We did the measurement using BUCHI NIR FLEX 500. We compared the result to blood glucose level by standard gold measurement. We also compared the Pearson correlation, and the standard deviation of all samples to then existing wavelength source LED provided by Thorlabs. We found that the highest absorbance and standard deviation wavelength is at 1939 nm. Wavelength LEDs candidates that represent measuring blood glucose levels is 1200, 1300, 1450, 1750, and 1950 nm. We did not find a severe adverse effect from each participant. Researchers should confirm the trial results with in vivo human observation.