Bittern as an Anti-Inflammatory on the Skin of Swiss Strain Mice

The study aimed to determine the quality of bittern lotion. Furthermore, this research aimed to determine the potential of bittern lotions as anti-inflammatory tests on the skin of Swiss Strain Mice using histological analysis. The bittern sample used was obtained from a salt pond in Kedung Mutih, Demak District, Central Java Province, Indonesia. The research was conducted by making lotion bittern in the concentrations of 20 percent, 35 %, and 50 %, followed by testing lotion bittern. The data were then analysed by One-Way ANOVA, LSD test, and Independent Samples T-test. Results showed that the three bittern lotions have potential as an anti-inflammatory, with the best results being 35% bittern lotion with an inflammatory inhibition (PI) level of 29.37%. However, based on histological analysis of the number of inflammatory cells (skin tissue), there was a significant difference (P<0.05). Thus, it can be concluded that bittern lotion has the potential as an anti-inflammatory lotion.