The biological effects of oral radioiodine administration on male rats (Rattus norvegicus): DNA damage and apoptosis

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Surniyantoro, Harry Nugroho Eko and Abinawanto, Abinawanto and Kisnanto, Teja and Ramadhani, Dwi and Saptiama, Indra and Basri, Iin K. H. and Fadhillah, Fadhillah and Lestari, Retno and Triningsih, Triningsih and Patrianesha, Bisma B. and Syaifudin, Mukh and Bowolaksono, Anom (2025) The biological effects of oral radioiodine administration on male rats (Rattus norvegicus): DNA damage and apoptosis. Journal of Radioanalytical and Nuclear Chemistry, 334 (7). pp. 4485-4493. ISSN 0236-5731, 1588-2780

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Official URL: https://doi.org/10.1007/s10967-025-10212-0

Abstract

The study evaluated the biological effects of oral radioiodine solution administration in rats, considering DNA damage and apoptosis. Rats were euthanized after treatment and assessed for markers for DNA damage and apoptosis. Results showed no significant variation in γ-H2AX levels in all organs but increased 8-OHdG concentrations in the thyroid and stomach after one day of radioiodine treatment. Caspase-3 levels in the thyroid increased 30 min after radioiodine therapy, suggesting a strong positive correlation between γ-H2AX and caspase-3. These findings could inform future research and clinical practice, particularly regarding DNA damage and apoptosis.

Item Type:	Article
Uncontrolled Keywords:	Apoptosis, Caspase-3, DNA damage, Oral radioiodine, γ-H2AX, 8-OhdG
Subjects:	Medicine & Biology Biomedical Technology & Human Factors Engineering
Depositing User:	Defryan Aprisandani
Date Deposited:	24 Aug 2026 07:59
Last Modified:	24 Aug 2026 07:59
URI:	https://karya.brin.go.id/id/eprint/59940

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