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DimensionsTourrette, Elise and Torres, Roberto C. and Svensson, Sarah L. and Matsumoto, Takashi and Miftahussurur, Muhammad and Fauzia, Kartika Afrida and Alfaray, Ricky Indra and Vilaichone, Ratha‐Korn and Tuan, Vo Phuoc and Aftab, Hafeza and Tshering, Lotay and Prasad, Dhakal Guru and Tshibangu‐Kabamba, Evariste and Tumba, Ghislain Disashi and Ngoma-Kisoko, Patrick de Jesus and Tshimpi-Wola, Antoine and Ngoyi, Dieudonné Mumba and Kashala, Pascal Tshiamala and Cruz, Modesto and Abreu, José Jiménez and Hosking, Celso and Ronkainen, Jukka and Aro, Pertti and Sugihartono, Titong and Syam, Ari Fahrial and Waskito, Langgeng Agung and Maulahela, Hasan and Rezkitha, Yudith Annisa Ayu and Panirani, Shaho Negahdar and Aghdaei, Hamid Asadzadeh and Zali, Mohammad Reza and Mirzaei, Nasrin and Latifi‐Navid, Saeid and Matsuhisa, Takeshi and Subsomwong, Phawinee and Terao, Hideo and Saruuljavkhlan, Batsaikhan and Shimoyama, Tadashi and Kinjo, Nagisa and Kinjo, Fukunori and Murakami, Kazunari and Myint, Thein and Aye, Than Than and Ni, New and Yee, Than Than and Htet, Kyaw Ko Ko and Shrestha, Pradeep Krishna and Sharma, Rabi Prakash and Rathnayake, Jeewantha and Lamawansa, M. D. and Rudbeck, Emilio and Agréus, Lars and Andréasson, Anna and Engstrand, Lars and Mahachai, Varocha and Ratanachu‐ek, Thawee and Pawa, Kammal Kumar and Trang, Trần Thị Huyền and Bình, Trần Thanh and Khien, Vu Van and Dung, Ho Dang Quy and Narith, Dou and Wang, Difei and Yadegar, Abbas and Olsson, Lisa and Zhou, Zhemin and Yamaoka, Yoshio and Thorell, Kaisa and Falush, Daniel (2024) An ancient ecospecies of Helicobacter pylori. Nature, 635 (8037). pp. 178-185. ISSN 0028-0836, 1476-4687
Full text not available from this repository. (Request a copy)Abstract
Abstract Helicobacter pylori disturbs the stomach lining during long-term colonization of its human host, with sequelae including ulcers and gastric cancer 1,2 . Numerous H. pylori virulence factors have been identified, showing extensive geographic variation 1 . Here we identify a ‘Hardy’ ecospecies of H. pylori that shares the ancestry of ‘Ubiquitous’ H. pylori from the same region in most of the genome but has nearly fixed single-nucleotide polymorphism differences in 100 genes, many of which encode outer membrane proteins and host interaction factors. Most Hardy strains have a second urease, which uses iron as a cofactor rather than nickel 3 , and two additional copies of the vacuolating cytotoxin VacA. Hardy strains currently have a limited distribution, including in Indigenous populations in Siberia and the Americas and in lineages that have jumped from humans to other mammals. Analysis of polymorphism data implies that Hardy and Ubiquitous coexisted in the stomachs of modern humans since before we left Africa and that both were dispersed around the world by our migrations. Our results also show that highly distinct adaptive strategies can arise and be maintained stably within bacterial populations, even in the presence of continuous genetic exchange between strains.
| Item Type: | Article |
|---|---|
| Subjects: | Natural Resources & Earth Sciences Medicine & Biology |
| Depositing User: | Rizzal Rosiyan |
| Date Deposited: | 04 Jun 2026 03:52 |
| Last Modified: | 04 Jun 2026 03:52 |
| URI: | https://karya.brin.go.id/id/eprint/58699 |
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