Antiplasmodial and anticancer activities of xanthones isolated from Garcinia bancana Miq.

This report describes the isolation and characterization of xantho-nes from Garcinia bancana Miq. and evaluates their antiplasmodialand anticancer activities. Macluraxanthone (1), isojacareubin (2),and gerontoxanthone C (3) were isolated from the stem bark ofG. bancana Miq. for the first time. In silico molecular docking stud-ies revealed the hydrogen bonding and steric interactions betweenxanthones (1–3) and PfLDH/VEGFR2. The in vitro antiplasmodialactivity was assayed against the chloroquine-sensitive Plasmodiumfalciparum strain 3D7 by the lactate dehydrogenase (LDH) method.The anticancer evaluation was evaluated against the A549, MCF-7,HeLa, and B-16 cancer cell lines. Compounds (1) (IC50 8.45–16.71 μM)and (3) (IC50 9.69–14.86 μM) showed more potent anticancer activitythan compound (2) (IC50 25.46–31.31 μM), as well for their anti-plasmodial activity (4.28 μM, 5.52 μM, 11.45 μM). Our findings indi-cated the potential of G. bancana Miq. as a natural resource ofantiplasmodial and anticancer compounds.