ANTIPLASMODIAL ACTIVITY AND MALATE QUINONE OXIDOREDUCTASE INHIBITOR OF STEROID ISOLATED FROM Fibraurea tinctoria

Malaria is an infectious disease that causes 400,000 deaths every year. Based on that fact, antimalarial exploration needs to be developed. This study aimed to explore another compound in Fibraurea tinctoria that is known to have antiplasmodial activity from the berberine compound. Lactate dehydrogenase (LDH) assay and malate quinone oxidoreductase (pfMQO) inhibitor assay against Plasmodium falciparum 3D7 was used to evaluate the activity. The result showed that methanol extract, n-hexane fraction, n-hexane subfraction, and steroid compounds isolated from nhexane subfraction had the potential ability to inhibit the growth of Plasmodium falciparum 3D7 as well as the pfMQO enzyme. The results indicate that Fibraurea tinctoria may serve as a promising medicinal plant for future antimalarial drug development.