A Novel Limonoid from the Seeds of Chisocheton macrophyllus

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Fajriah, Sofa and Farabi, Kindi and Nurlelasari, Nurlelasari and Huda, Muhammad Badrul and Safriansyah, Wahyu and Supratman, Unang and Budiman, Yudha P. and Huspa, Desi Harneti P. and Maharani, Rani and Mayanti, Tri (2024) A Novel Limonoid from the Seeds of Chisocheton macrophyllus. Records of Natural Products, 18 (3). pp. 347-351. ISSN 1307-6167

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Official URL: https://doi.org/10.25135/rnp.451.2311.2960

Abstract

This study aimed to isolate a novel limonoid compound, (6R,7S, 8R, 9R, 10R, 11R, 13S, 17R)-17- (furan-3-yl) -4, 4, 8, 10, 13-pentamethyl-3-oxo-4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 16, 17-dodecahydro-3Hcyclopenta[a]phenanthrene-6,7,11-triyltriacetate (11α-acetoxydysobinin) (1), and 3 pre-existing limonoids, namely dysobinin (2), dysobinol (3), and 7-deacetylepoxyazadiradione (4) from the seeds of Chisocheton macrophyllus (Meliaceae). In addition, the structure of the isolated compounds was determined using various spectroscopic techniques, including UV, IR, HRTOFMS, 1D, and 2D NMR. The cytotoxic effects of each compound were then evaluated against breast cancer cells of the Michigan Cancer Foundation-7 (MCF-7), but no significant activity was observed

Item Type:	Article
Uncontrolled Keywords:	Chisocheton macrophyllus; Meliaceae; limonoid; cytotoxic activity; MCF-7
Subjects:	Medicine & Biology Chemistry
Depositing User:	Rizzal Rosiyan
Date Deposited:	18 May 2026 07:13
Last Modified:	18 May 2026 07:14
URI:	https://karya.brin.go.id/id/eprint/58437

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