Literature review: Association of genetic polymorphism effect on risk events of diabetes mellitus

Elvira, Yunita and Cindy Ernica, Putri and Audia, Indrian and Liya Agustin, Umar and Diah Ayu Aguspa, Dita (2022) Literature review: Association of genetic polymorphism effect on risk events of diabetes mellitus. Jurnal Medika Malahayati, 6 (4): 1. 403 -410. ISSN 2355-6757

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Diabetes is a condition of long-term/chronic metabolic disorders characterized by high blood glucose levels caused by absolute or relative insulin deficiency, β cell dysfunction, insulin resistance or both. Diabetes mellitus is classified into several types, and the most commonly known are type 1 and type 2 diabetes mellitus. Factors associated with the incidence of DM include overweight, central/abdominal obesity, degree of stress, lack of physical activity, hypertension, dyslipidemia, prediabetes condition, smoking, race, ethnicity, age, gender, family
history of diabetes mellitus. Genetic factors are known to have an important role in the incidence, course and development of DM. The most common genetic factor that plays a role is Single Nucleotide Polymorphism (SNP). Genes that are known to have a close relationship with DMT1 include the HLA, CTLA-4, PTPN22, and IL2RA/CD25 genes. In DMT2 there are several genes that play a role such as ABCC8, KCNJ11, PPAR-γ and CALPN10 genes.

Item Type: Article
Uncontrolled Keywords: Genetic, Mellitus, Polymorphism, risk, Risk factors, Metabolic disorders, Diabetes
Subjects: Medicine & Biology > Clinical Medicine
Medicine & Biology > Physiology
Depositing User: - Elfrida Meryance Saragih
Date Deposited: 25 Sep 2023 04:04
Last Modified: 25 Sep 2023 04:04

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