The Relationship between Expression of p70s6k with Radiotherapy Response in Cervical Cancer

There are many important prognostic factors in advanced stage cervical cancer
primary treated with radiotherapy. Besides clinical factors, many biomarkers have
been studied in relation with radiotherapy response. The p70s6k is a biomarker
which plays a significant role in cell proliferation. Increased levels of p70s6k are
also associated with drug resistance in cancer. In the present study, the relationship
between the expression level of p70s6k before treatment and the radiotherapy
response in cervical cancer was determined. Immunohistochemical staining of
p70s6k, MIB-1, and p53 was conducted in microscopic slide from 21 cancer tissue
biopsies before treatment with radiotherapy. After the treatment had completed
early radiotherapy response was observed by pelvic control method. The results
showed that p70s6k is partly highly expressed (61.9%, 13/21) and partly low
expressed (38.1%, 8/21) in the cancer cells. They also show that there is no
statistically significant differences on AgNOR mean, MIB-1, and p53 indices in the
different degrees of p70s6k expression (p≥0.05). Higher expression levels of p70s6k
is more strongly associated with good radiotherapy response compared to lower
ones (p=0.05). In conclusion, the level of p70s6k expression before treatment has an
association with radiotherapy response.