Liu, Wen-chi and Oikawa, Masato and Fukase, Koichi and Suda, Yasuo and Winarno, Hendig and Mosi, Saeko (1997) Enzymatic Preparation of (S)-3-Hydroxytetradecanoic Acid and Synthesis of Unnatural Analogues of Lipid A Containing the (S)-Acid. Bulletin of the Chemical Society of Japan, 70 (6). pp. 1441-1450.
bcsj.70.1441
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Abstract
Synthesis of unnatural analogues, that contain (S)-3-hydroxytetradecanoyl moieties in place of the corresponding natural (R)-isomers, of both lipid A and its biosynthetic precursor, designated precursor Ia or lipid IVA, has been achieved through our recently developed procedure. (S)-3-Hydroxytetradecanoic acid was prepared from its racemate through the optical resolution by the use of a lipase and subsequent fractional recrystallization. The (S)-acyl analogue of lipid A exhibited slightly stronger interleukin-6 inducing activity than the corresponding natural lipid A, and the (S)-acyl analogue of the biosynthetic precursor was far more active than the natural precursor in inhibiting the induction of interleukin-6 by lipopolysaccharide.
Item Type: | Article |
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Subjects: | Taksonomi BATAN > Isotop dan Radiasi > Pemanfaatan Isotop dan Radiasi > Bidang Kesehatan |
Divisions: | BATAN > Pusat Aplikasi Isotop dan Radiasi IPTEK > BATAN > Pusat Aplikasi Isotop dan Radiasi |
Depositing User: | Administrator Repository |
Date Deposited: | 27 May 2018 15:08 |
Last Modified: | 02 Jun 2022 02:46 |
URI: | https://karya.brin.go.id/id/eprint/2427 |