Relationship Between Polymorphisms of DNA Repair Gene XPD 23 With Frequency of Micronuclei in Cervical Cancer Patients

Cervical cancer is an important health problem, especially in developing countries like Indonesia. Radiotherapy is a major treatment modality for invasive cervical cancer with good treatment outcomes in early-stage patients and plays integral role in the combined-modality management of cervical cancer. Substantial variation in the intrinsic response of individuals to radiation can be seen from the polymorphism of DNA repair genes. DNA repair systems are responsible for maintaining the integrity of the genome and have a critical role in protecting against mutations that can lead to cancer. DNA damage can turn into chromosome alterations that are detected by the micronucleus (MN) assay. Micronuklei (MN) is one indication of structural damage to the chromosomes caused by radiation that can be observed in a cell with two nuclei (binukleat), by blocking the division process at the stage of cytokinesis using sitokalasin B known as cytokinesis Block (CB). The aim of this study is for relationship between polymorphisms of DNA repair gene XPD 23 with micronuclei in cervix cancer patients. From a sample of cervical patients before
radiotherapy obtained a strong relationship (r = 0.602) but not significant (p = 0.153).