Triterpenoids from stem bark of Dysoxylum excelsum and their cytotoxic activity against MCF-7 breast cancer cells

Sylvia, Rachmawati Meilanie and Tri, Mayanti and Nurlelasari, Nurlelasari and Desi, Harneti Putri Huspa and Rani, Maharani and Achmad, Zainuddin and Darwati, Darwati and Euis, Julaeha and Unang, Supratman and Jamaludin, Al Anshori (2022) Triterpenoids from stem bark of Dysoxylum excelsum and their cytotoxic activity against MCF-7 breast cancer cells. Indonesian Journal of Chemistry (Indones. J. Chem), 22 (4): 20. pp. 1107-1115. ISSN 1411-9420 e_ISSN: 2460-1578

[thumbnail of Jurnal_Sylvia Rachmawati Meilanie_Universitas Padjadjaran_2022.pdf]
Jurnal_Sylvia Rachmawati Meilanie_Universitas Padjadjaran_2022.pdf - Published Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (2MB) | Preview


The diversity of structures of triterpenoids provides a variety of interesting pharmacological effects, one of them being anticancer. Sources of triterpenoids are found in Dysoxylum excelsum, it is still rarely studied, and it potentially contains triterpenoids with cytotoxic activity. Therefore, the research aimed to isolate the triterpenoids from the stem bark of D. excelsum and determine their cytotoxic efficacy against the breast cancer cells of MCF-7. The dried stem bark of D. excelsum was macerated using methanol and then fractionated with n-hexane and ethyl acetate to obtain the corresponding fractions. Two triterpenoids, 3α,7α-dihydroxyapotirucalla-14,24-Z-dien-26-oic acid (1) and masticadienonic acid or 3-oxo-tirucalla-7,24-Z-dien-26-oic acid (2) were isolated in the first place from the Dysoxylum genus. Compounds 1 and 2 were assayed for their cytotoxic potency anti- MCF-7 using the MTT assay and gave moderate IC50 values of 60.87 and 72.86 µM, respectively. Based on their analogs, partial structure modification of the compounds might increase the activity; thus, it can be further utilized as better lead compounds for anticancer drugs candidate.

Item Type: Article
Uncontrolled Keywords: Dysoxylum excelsum, Triterpenoids, Meliaceae, Cytotoxic, MCF-7 breast cancer
Subjects: Medicine & Biology
Medicine & Biology > Pharmacology & Pharmacological Chemistry
Chemistry > Analytical Chemistry
Depositing User: Djaenudin djae Mohamad
Date Deposited: 12 May 2023 04:40
Last Modified: 12 May 2023 04:40

Actions (login required)

View Item
View Item