Free fatty acids regulating action of Capparis decidua fruit on dyslipidemia in rats

Avijit, Saha and Sangeeta, Ghosh and Alok, K. Hazra and Sandip, Ghosh and Tapas, Kumar Sur (2022) Free fatty acids regulating action of Capparis decidua fruit on dyslipidemia in rats. Pharmaciana: Jurnal Kefarmasian, 12 (2): 6. pp. 188-195. ISSN 2088 4559

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Capparis decidua belongs to family Capparidaceae in wastelands of India. The study aim was to determine the role of C. decidua fruits on the free fatty acids (FFA) profile in fat-rich diet (FRD) dyslipidemic rats. The methanolic extract of edible fruit of C. decidua (CD) was given orally to obese dyslipidemic rats at the dose of 125 mg/kg and 250 mg/kg for consecutive 28 days. CD treatment in FRD rats significantly restricts the body weight gains. Blood lipid profile was altered dose dependently and significantly after 4-week treatment with CD to FRD. rats. It significantly (p<0.05) enhanced serum FFA especially, γ-linolinate, α-linolinate, arachidonate, ecosapentaenoate, docosapentaenoate and docosahexaenoate. Moreover, ⱷ-PUFA content was also enhanced (50.3% and 78.8%) in the serum of CD treated animals, whereas MUFA was lowered (31.1% and 40%). Therefore, Capparis decidua fruit has a promising role on dyslipidemia and obesity and has the capabilities to regulate beneficial free fatty acids.

Item Type: Article
Uncontrolled Keywords: Obesity, Dyslipidemia, FFA, PUFA, GC, Capparis decidua
Subjects: Medicine & Biology > Pharmacology & Pharmacological Chemistry
Depositing User: Djaenudin djae Mohamad
Date Deposited: 06 Mar 2023 10:42
Last Modified: 06 Mar 2023 10:42

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