Multifunctional microsphere formulation of fluorescent magnetic properties for drug delivery system

Eny Kusrini; Riesna Prassanti; Dwi Marta Nurjaya; Cindy Gunawan

doi:10.1063/1.4976780

Abstract

The microsphere formulations of Chit/TPP/Sm/Fe₃O₄/Rn were prepared by an ionic gelation technique, where Chit=chitosan, TPP=tripolyphosphate, Sm=samarium and Rn=ranitidine. Optimum of microsphere formulation exhibit magnetic and fluorescent properties with adsorption efficiency of ∼92% was obtained for Chit/TPP/Sm/Fe₃O₄/Rn with ratio 400:500:50:1:20. Fluorescence intensity of microsphere formulations increased with the cumulative amount release of ranitidine, so that the changing of fluorescence intensity at wavelength of 590 nm referring to the Sm³⁺ ion could be used as indicator in DDS. With the demonstration of sustained release from microsphere formulation, it allows to investigate the applications to other drugs.

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