Studi Awal Pembuatan Koloid Kromik Fosfat Bertanda Radioisotop 32P Sebagai Bahan Pembuatan Skin Patch

Abstract

Keloids are skin disorders or benign tumors that are due to abnormal wound healing in the binding tissue after a trauma, inflammation, surgical wounds, or burns. Low activity radioisotopes have shown to be effective in curing or eliminating keloids on the skin. One of these radioisotopes is phosphorus-32 (³²P), a beta (β^-) emitter with a half-life of 14.3 days. This radioisotope can also be developed for the treatment of keloid and skin tumors. Currently, keloid is treated by a conventional method e.g. by applying the bulk of ³²P radioisotope directly on keloid area and this method is considered inefficient and less secure. The purpose of this research is to obtain technology for preparing of a ³²P-labeled skin patch. The first step of this research is to produce ³²P-labeled chromic phosphate (Cr³²PO₄) colloids, through condensation involving oxidation-reduction reaction. In this step, Cr (VI) is reduced to Cr (III) to form Cr³²PO₄ with a particle size of <1 μm.  These particles (Cr³²PO₄) are to expect to distribute evenly when mixed with silicon to form skin patch which will not decompose easily.  Characterization of the prepared Cr³²PO₄ colloids gave a yield of 97,8%. Geometric standard deviation (sg) of colloidal particles amounted to 163.7 nm shaped poly-disperse.  Further study needs to be performed in due time in order to have Cr³²PO₄ colloids with suitable particle size.