EVALUASI PROSES PRODUKSI RADIOISOTOP Sm-153 DAN SEDIAAN RADIOFARMAKA Sm-153 EDTMP
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EVALUASI PROSES PRODUKSI RADIOISOTOP Sm-153 DAN SED1AAN RADIOFARMAKA Sm-153 EDTMP. Telah dilakukan percobaan proses produksi radioisotop Sm-153 dan proses penandaan sediaan radiofarmaka Sm-153 EDTMP, yang bertujuan untuk mengevaluasi proses produksi radioisotop Sm-153 dan sediaan radiofarmaka Sm-153 EDTMP di Pusat Radioisotop dan Radiofarmaka, BATAN. Dalam percobaan ini mencakup penyiapan bahan sasaran Sm2O3, pelarutan pasca irradiasi, penetapan konsentrasi radioaktivitas isotop Sm-153, kemurnian radionuklida, proses penandaan senyawa EDTMP, penetapan kemurnian radiokimia dan pH. Dalam percobaan ini diperoleh produk radioisotop Sm-153 dengan radioaktivitas total antara 2845,83 mCi s/d 36963,31 mCi atau dengan konsentrasi radioaktivitas antara 474,30 mCi/ml sampai dengan 6160,55 mCi/ml) berbentuk larutan SmCl3yang masing-masing mempunyai volume 6,0 ml, kandungan samarium 5,76 mg/ml dan dengan kemurnian radionuklida dari produk radioisotop Sm-153 adalah 100 %. Semua produk sediaan radiofarmaka Sm-153 EDTMP memenuhi syarat konsentrasi radioaktivitas, kandungan Sm, kemurnian radiokimia dan pH. Konsentrasi radioaktivitas sediaan radiofarmaka Sm-153 EDTMP minimum 37,50 mCi/ml dan yang terbesar 283,50 mCi/ml, sebanyak 8 buah larutan mempunyai pH 7,5, sedangkan yang lainnya ( 2 buah larutan ) mempunyai pH sebesar 8,5. Kemurnian radiokimia sediaan raiofarmaka Sm-153 EDTMP berkisar antara 90,00 % sampai dengan 98,76 %.
Kata Kunci : Evaluasi, Radioisotop, Radiofarmaka, Sm-153, Sm-153 EDTMP
EVALUATION OF RADIOISOTOPE PRODUCTION PROCESS OF Sm-153 AND Sm-153 EDTMP RADIOPHARMACEUTICALS. Experiments on the process of Sm-153 radioisotope and labeling of Sm-153 EDTMP radiopharmaceuticals were carried out, as a purpose for evaluation of Sm-153 radioisotope and Sm-153 EDTMP process production in Center for Radioisotope and Radiopharmaceuticals, National Nuclear Energy Agency. This experiments included preparation of Sm2O3target, dissolution of post irradiation, determination of radioactivity concentration of Sm-153 radioisotope, radionuclide purity, EDTMP labeling, determination of radiochemicals purity and pH. In these experiments the total radioactivity Sm-153 product is about 2845.83 mCi to 36963,31 mCi, or with the radioactivity concentration between 474,30 mCi/ml and 6160,55 mCi/ml in the SmCl3solution form. The volume is 6.0 ml, the samarium content is 5.76 mg/ml and the radionuclide purity of Sm-153 is 100 %. All of the Sm-153 EDTMP radiopharmaceuticals product are fullfilled requirements the radioactivity concentration, Sm content, radiochemical purity and pH. The radioactivity concentration of Sm-153 EDTMP radiopharmaceuticals is 37,50 mCi/ml(minimum) to 283,50 mCi/ml (highest). The pH 7.5 were 8 products, and the rest are pH 8.5. Radiochemical purity of Sm-153 EDTMP are round about 90.00 % to 98,76 %.
Key Words : evaluation, radioisotope, radiopharmaceutical, Sm-153, Sm-153 EDTMP
Kata Kunci : Evaluasi, Radioisotop, Radiofarmaka, Sm-153, Sm-153 EDTMP
EVALUATION OF RADIOISOTOPE PRODUCTION PROCESS OF Sm-153 AND Sm-153 EDTMP RADIOPHARMACEUTICALS. Experiments on the process of Sm-153 radioisotope and labeling of Sm-153 EDTMP radiopharmaceuticals were carried out, as a purpose for evaluation of Sm-153 radioisotope and Sm-153 EDTMP process production in Center for Radioisotope and Radiopharmaceuticals, National Nuclear Energy Agency. This experiments included preparation of Sm2O3target, dissolution of post irradiation, determination of radioactivity concentration of Sm-153 radioisotope, radionuclide purity, EDTMP labeling, determination of radiochemicals purity and pH. In these experiments the total radioactivity Sm-153 product is about 2845.83 mCi to 36963,31 mCi, or with the radioactivity concentration between 474,30 mCi/ml and 6160,55 mCi/ml in the SmCl3solution form. The volume is 6.0 ml, the samarium content is 5.76 mg/ml and the radionuclide purity of Sm-153 is 100 %. All of the Sm-153 EDTMP radiopharmaceuticals product are fullfilled requirements the radioactivity concentration, Sm content, radiochemical purity and pH. The radioactivity concentration of Sm-153 EDTMP radiopharmaceuticals is 37,50 mCi/ml(minimum) to 283,50 mCi/ml (highest). The pH 7.5 were 8 products, and the rest are pH 8.5. Radiochemical purity of Sm-153 EDTMP are round about 90.00 % to 98,76 %.
Key Words : evaluation, radioisotope, radiopharmaceutical, Sm-153, Sm-153 EDTMP
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